BEST-Fluids

best-fluids-logo-2016

The effect of a low-chloride balanced crystalloid solution compared with 0.9% saline on kidney transplant graft function; a multi-centre phase III randomised controlled trial

Principal Investigator: Dr Michael Collins

Adults and children who are admitted for deceased donor kidney transplant will be given either Plasma-Lyte© 148 or a normal Saline solution (0.9% sodium chloride) and the primary outcome is a composite of the duration of Delayed Graft Function (requirement of dialysis) and the rate of recovery of draft function (creatine reduction ratio). The target recruitment for this study is 574 participants. Funding has been secured to initiate phase 1 of the trial development and recruitment, and an NHMRC grant has been submitted in 2017 to seek funding for phase 2.