IMpact of Phosphate Reduction On Vascular End-points in Chronic Kidney Disease

Principal Investigator: Dr Nigel Toussaint and Dr Eugenie Pedagogos
Project Officer: Andrea Valks (AKTN)
Trial Number: AKTN 10.01

Population: CKD stage 3b/4 patients
Intervention: Lanthanum carbonate (1500-3000mg) vs placebo, daily
Follow-up: 24 months
Primary outcome: Arterial compliance (PWV)
Status: Data analysis is underway

Recruitment end date: 31 December 2016
Follow-up end date: December 2018
Recruitment: 278/488

Trial Summary:

Chronic kidney disease (CKD) is a significant health problem and is associated with an increased risk of cardiovascular (CV) disease. Vascular calcification and arterial stiffness (stiffening of the blood vessels and arteries) are very common in people with CKD, and are linked to increased death from CV events. This study aims to examine the ways in which treatment with a phosphate binder, Lanthanum Carbonate, may reduce vascular calcification and arterial stiffness to decrease CV events.

Click here to view the Statistical Analysis Plan.

Read the full publications via the links below.
IMPROVE Dietary Phosphate Study Baseline Characteristics – Journal of Renal Nutrition 2020
IMPROVE Baseline Characteristics – American Journal of Nephrology 2020
IMPROVE Protocol – BMJ Open 2019