A Data & Safety Monitoring Board (DSMB) is an independent body of clinicians, statisticians and individuals from other disciplines whose task is to review accumulating trial data and make recommendations to the Trial Steering Committee concerning the conduct of the trial and whether the trial should continue in its current form. The primary objective of a DSMB is to ensure that the trial remains appropriate and safe for individuals who have been, or are still to be, enrolled. Other responsibilities include monitoring trial progress and overall quality of trial conduct.
Members of current and past DSMBs and the trials they monitored are as follows.
Current DSMB
IMPROVE-CKD; CKD-FIX; TEACH-PD and BEST-Fluids Trials
Members
Bruce Neil (Chair)
Andrew Forbes
David Wheeler
Christoph Wanner
PHOSPHATE Trial
Members
Christoph Wanner (Chair)
Andrew Forbes
Anthony Keech
Bryan Kestenbaum
Miles Witham
GOAL Trial
Members
Suetonia Palmer (Chair)
Sabine Braat
Vasi Naganathan
Elizabeth Ryan
IMPEDE-PKD and INCH-HD Trials
Members
Christoph Wanner (Chair)
Ron.T. Gansevoort
Andrew Forbes
David Wheeler
BEAT-BK Trial
Members
Christoph Wanner (Chair)
Camille Kotton
Klemens Budde
Liz Ryan
Current Safety Monitoring Committee
NAVKIDS2 Trial
Members
Tom Snelling (Chair)
David Issacs
Nicholas Larkin
Past DSMB
HERO; FAVOURED and HONEYPOT Trials
Members
Andrew Tonkin (Chair)
Andrew Forbes
Adeera Levin
David Wheeler
BLOCADE Trial
Members
Adeera Levin (Chair)
Andrew Martin
David Hare
David Wheeler