A Data & Safety Monitoring Board (DSMB) is an independent body of clinicians, statisticians and individuals from other disciplines whose task is to review accumulating trial data and make recommendations to the Trial Steering Committee concerning the conduct of the trial and whether the trial should continue in its current form. The primary objective of a DSMB is to ensure that the trial remains appropriate and safe for individuals who have been, or are still to be, enrolled. Other responsibilities include monitoring trial progress and overall quality of trial conduct.
The AKTN currently has one DSMB which is responsible for monitoring accumulating data for the IMPROVE-CKD and CKD-FIX trials. The DSMB met in March 2015 and recommended both trials continue under their current protocols.
Members of current and past DSMBs and the trials they monitored are as follows.
IMPROVE-CKD and CKD-FIX Trials
Bruce Neil (Chair)
HERO, FAVOURED and HONEYPOT Trials
Andrew Tonkin (Chair)
Adeera Levin (Chair)