Omega-3 Fatty Acids (fish Oils) and Aspirin in Vascular access OUtcomes in REnal Disease

Principal Investigator: Dr Ashley Irish
Clinical Research Associate: Peta-Anne Paul-Brent (AKTN)

Population: Stage 3/4 CKD patients undergoing or planning to undergo Haemodialysis with planned de novo AVF

Final recruitment number: 567 (target of 650)
Intervention: Aspirin (100mg) and/or Omega-3 (4,000mg) fatty acids versus placebo, daily for 12 weeks
Primary outcome: AVF Access Failure rate over 12 months

Results: The FAVOURED study is unable to recommend the use of fish oil or aspirin for the prevention of AVF failure. Additional studies and strategies to reduce the current unacceptably high AVF failure rate are urgently required. The results of the study have been presented as the ASN Kidney Week in November 2015 and the final results paper and the final results has been published in JAMA Internal Medicine Effect of Fish Oil Supplementation and Aspirin Use on Arteriovenous Fistula Failure in Patients Requiring Hemodialysis: A Randomized Clinical Trial. Irish AB, Viecelli AK, Hawley CM, Hooi LS, Pascoe EM, Paul-Brent PA, Badve SV, Mori TA, Cass A, Kerr PG, Voss D, Ong LM, Polkinghorne KR; Omega-3 Fatty Acids (Fish Oils) and Aspirin in Vascular Access Outcomes in Renal Disease (FAVOURED) Study Collaborative Group. JAMA Intern Med. 2017 Feb 1;177(2):184-193. doi: 10.1001/jamainternmed.2016.8029).

Click here to view the Statistical Analysis Plan.