Randomised Evaluation of SOdium dialysate Levels on Vascular Events: A cluster clinical study
Principal Investigators: Professor Meg Jardine
In the RESOLVE study, haemodialysis units Australia, New Zealand, China, India and other interested countries will be cluster randomised by unit to receive one of two sodium dialysate levels (137mmol/L or 140mmol/L). Major cardiovascular events (i.e. myocardial infarction, hospitalised heart failure, stroke and all-cause death) are being reported pragmatically within existing data collection systems where available (i.e. ANZDATA Registry in Australia and New Zealand). New Zealand HRC and Australian NHMRC project funding have been granted. International collaboration is led by the George Institute, Sydney and Australian collaboration is led by the Australasian Kidney Trials Network.
Recruitment: 3565 in Australia (updated 11 March 2021)